Prognostic and immunotherapeutic response prediction in hepatocellular carcinoma: role of non-histone acetylation/deacetylation scoring.

ABSTRACT:

Background

Post-translational modification is crucial, with acetylation and deacetylation enzymes playing important roles. Their roles in liver cancer, however, remain unclear.

Methods

In this study, a KAT + KDAC score was developed to assess the prognosis and response to immunotherapy in liver cancer patients. The association of HDAC1, HDAC2, and HDAC3 with patient prognosis was analyzed, and the PPI network was constructed. The correlation between the score and P53 mutation status, stage, and TNM staging was also investigated. Additionally, the response to chemotherapy was evaluated. The TIDE score was also assessed.

Results

Our analysis showed that HDAC1, HDAC2, and HDAC3 are highly associated with patient prognosis and are centrally located in the PPI network. Pat

SUBMITTER: Li J 

PROVIDER: S-EPMC12332175 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature