Beta cyclodextrin stabilized cupric oxide nanoparticles assisted thermal therapy for lung tumor and its effective in vitro anticancer activity.

ABSTRACT: The unique physicochemical properties of cupric oxide nanoparticles (CuO NPs) make them suitable for a wide range of therapeutic applications. Here, we synthesized β-cyclodextrin (βCD) capped CuO NPs (CuONPs@βCD) using a simple reduction process. The formation and physicochemical characteristics were identified via different spectroscopic techniques. The CuONPs@βCD displayed antimicrobial activity as good as commercial drugs. Dimethyl thiazolyl tetrazolium bromide (MTT) assay was carried out to assess the anticancer properties of CuONPs@βCD against A549 lung cancer cells. The result demonstrated that the anticancer activity of CuONPs@βCD with IC₅₀ values of 41.06 ± 0.05 and 19.46 µg/mL at 24 and 48-h incubation period, respectively. CuONPs@βCD exhibited anticancer activity on A5

SUBMITTER: Rajeeve AD 

PROVIDER: S-EPMC12332176 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature