Growth phase diets diminish histone acetyltransferase Gcn5 function and shorten lifespan of Drosophila males.

ABSTRACT: The nutritional environment in early life, referred to as the nutrition history, exerts far-reaching health effects beyond the developmental stage. Here, with Drosophila melanogaster as a model, we fed larvae on diets consisting of a variety of yeast mutants and explored the resulting histories that impacted adult lifespan. A larval diet comprised of yeast nat3 KO shortened the lifespan of male adults; and remarkably, this diet diminished the function of histone acetyltransferase Gcn5 in larvae. Concordantly, perturbation of Gcn5-mediated gene regulation in the larval whole body or neurons significantly contributed to the earlier death of adults. The nat3 KO diet is much more abundant in long-chain fatty acids and branched-chain amino acids (BCAAs) than the control yeast diet. Supplementin

SUBMITTER: Mizutani S 

PROVIDER: S-EPMC12332192 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature