Comprehensive Literature Review Evaluating the Use, Safety, and Efficacy of Subcutaneous Methotrexate in the Treatment of Adult Patients With Moderate-To-Severe Plaque-Type Psoriasis.

ABSTRACT: Methotrexate (MTX) is a conventional systemic therapy widely used to treat chronic plaque-type psoriasis, a chronic inflammatory skin disease that significantly impacts patients' quality of life. MTX can be administered orally or subcutaneously. Over the past decades, the use of subcutaneous versus oral MTX has been a subject of ongoing debate among dermatologists. Therefore, this literature review aimed to investigate the differences between oral and subcutaneous MTX described in the scientific literature in terms of intestinal absorption and bioavailability, efficacy, safety, patient satisfaction and quality of life, treatment adherence, and economic outlook. Thirty-two articles were included in the review, notably including evidence-based guidelines on the management of psoriasis, as we

SUBMITTER: Viguier M 

PROVIDER: S-EPMC12332243 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature