Relationship Between the Lactate-to-Albumin Ratio and 28-Day Overall Mortality in Critically Ill Patients with Pulmonary Embolism: A Retrospective Analysis of the MIMIC-IV Database.

ABSTRACT: BackgroundThe lactate-to-albumin ratio (LAR) has prognostic value in various clinical conditions, but its association with mortality in pulmonary embolism (PE) remains unclear. This study aims to investigate the relationship between LAR and 28-day all-cause mortality in PE patients.MethodsThis retrospective observational study used MIMIC-IV database, with 28-day mortality as the primary endpoint. Adjusted Cox models were used to assessed the LAR-mortality association, with subgroup analyses for stability. Kaplan-Meier curves estimated mortality across LAR tertiles. Restricted cubic spline(RCS) analysis evaluated nonlinearity. Receiver operating characteristic curves(ROC) and reclassification metrics were used to compare the predictive performance of LAR with the Pulmonary Embolism Severity

SUBMITTER: Xu J 

PROVIDER: S-EPMC12332334 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature