A Protein Corona-Based Diagnostic Tool for Eroded Atherosclerotic Plaques.

ABSTRACT: Superficial plaque erosion, distinct from plaque rupture, represents a cause of residual thrombotic complications in atherosclerosis. Being able to detect plaque erosion, a mechanism that now accounts for up to 30% of acute coronary syndromes, can lead to targeted therapies, and perhaps avoid the need for urgent invasive interventions required for plaque rupture cases, thus greatly affecting clinical management. Nanoparticles (NPs) exposed to biological fluids acquire a layer of proteins on their surface, the protein corona (PC). Variations in the composition of the plasma proteome occurring in pathological conditions directly influence the composition of the PC. An NP-based diagnostic approach is presented exploiting the proteomic changes at the nano-bio interface for superficial plaque e

SUBMITTER: Tobar Leitao SA 

PROVIDER: S-EPMC12332804 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature