Ceragenin Nanogel Coating Prevents Biofilms Formation on Urinary Catheters.

ABSTRACT: Catheter-associated urinary tract infections (CAUTIs) account for 40% of hospital-acquired infections, increasing health risks, patient discomfort, morbidity, and hospitalisation time. Bacterial colonisation may occur both during catheter insertion and prolonged catheterization by microorganisms in the urinary tract, consequently, increasing the bacteriuria risk due to biofilm formation. Nanogels, a class of soft nanocarriers, offer remarkable versatility for developing functional coatings on indwelling medical devices that can efficiently prevent biofilm formation. In this study, we designed an antibacterial and antibiofilm coating by leveraging the ultrasound-assisted assembly and nanogel self-organization on silicone catheters. The nanogel comprising biocompatible gum arabic and poly(di

SUBMITTER: Puertas-Segura A 

PROVIDER: S-EPMC12332827 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature