Label-Free Electrochemical Interleukin-6 Sensor Exploiting rGO-Ti₃C₂T_<i>x</i> MXene Nanocomposites.

ABSTRACT: This work introduces a novel, rapid, label-free, affinity-enabled electrochemical sensor for the detection of interleukin-6 (IL-6), a critical proinflammatory cytokine associated with severe conditions like sepsis and COVID-19. Unlike conventional approaches, this platform leverages an innovative biofunctional nanocomposite of Ti₃C₂T_x MXene, tetraethylene pentaamine-functionalized reduced graphene oxide (TEPA-rGO), and Nafion, functionalized with anti-IL-6 antibodies, integrated into a carbon-based screen-printed three-electrode chip. The system achieves unprecedented sensitivity in IL-6 quantification, with a single-digit pg/mL detection limit and a broad range of 3-1000 pg/mL using ∼5 μL of serum. The sensor design is uniquely enhanced through the

SUBMITTER: Gupta R 

PROVIDER: S-EPMC12332829 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature