Morphology Effect of PEGylated Iron Oxide Nanoparticles on the Enhancement of MRI Contrast Signal in Breast Cancer.

ABSTRACT: MRI is one of the most powerful imaging modalities to diagnose cancer at early stages, which can be further improved with contrast agents (CAs). For this purpose, iron oxide nanoparticles (IONs) are commonly used as T₂ probes to enhance the contrast in MRI scans. The morphology of IONs plays an important role in determining their contrast abilities when exposed to external magnetic fields, yet the underlying mechanism remains elusive. To better understand the relationship of T₂ relaxation with anisotropic-shaped IONs (ASIONs), we produced PEG-IONs with similar core geometrical volumes and different morphologies─spheres (SIONs), cubes (CIONs), and rhombohedra (RIONs). We then compared their effectiveness as MRI CAs to commercially available ferumoxytol (F

SUBMITTER: Minier S 

PROVIDER: S-EPMC12332843 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature