Control of physiologic glucose homeostasis via hypothalamic modulation of gluconeogenic substrate availability.

ABSTRACT:

Objectives

The brain mobilizes glucose in emergency situations such as hypoglycemia as well as during day-to-day physiology such as fasting. While most hypothalamic neuronal populations that contribute to glucose mobilization also contribute to other aspects of metabolism, neurons in the ventromedial nucleus of the hypothalamus that express the cholecystokinin b receptor (VMH^Cckbr neurons) support glucose production during hypoglycemia without controlling energy homeostasis. However, their role in day-to-day glucose physiology and the mechanisms they engage to support glucose mobilization is unclear.

Methods

We used continuous glucose monitoring in mice with chronically silenced VMH^Cckbr neurons to establish whether these neurons are required during day

SUBMITTER: Su J 

PROVIDER: S-EPMC12332875 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature