Serum uric acid levels and the risk of hemorrhagic stroke: Insights from a two-sample Mendelian randomization study.

ABSTRACT:

Background and aims

Observational studies have indicated a potential association between serum uric acid levels and the risk of intracerebral hemorrhage and subarachnoid hemorrhage. To explore whether this relationship is causal, the authors performed a two-sample Mendelian randomization analysis.

Methods and results

The authors sourced data on single-nucleotide polymorphisms related to serum uric acid levels from the European Bioinformatics Institute ‒ Association database, along with information on intracerebral hemorrhage and subarachnoid hemorrhage from the same repository. The primary analysis for the Mendelian Randomization was conducted using the inverse variance weighted method, accompanied by sensitivity analyses to validate the findings. The Mendelian Randomization

SUBMITTER: Wang ZW 

PROVIDER: S-EPMC12332956 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature