Comparison of age-related inflammation and oxidative stress in two lemur species.

ABSTRACT: Oxidative damage and inflammation are mechanisms proposed to contribute to physiological senescence. Variation in oxidative damage and inflammation may reflect differential allocation of resources to reproduction and survival, contributing to differences in species-typical longevity and resulting from distinct, evolved life-history strategies. To investigate the link between molecular processes and physiological senescence, we compared urinary biomarkers of oxidative stress (8-isoprostane and 8-OHdG) and inflammation (neopterin) in a cross-sectional sample of two species that differ in life-history schedules: the relatively fast-paced ring-tailed lemur (Lemur catta; n = 41; ages = 1-32 years) and slow-paced Coquerel's sifaka (Propithecus coquereli; n = 49; ages = 1-27 years). Consistent wi

SUBMITTER: Guevara EE 

PROVIDER: S-EPMC12332973 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature