Contrast-enhanced ultrasound and elastography predict histopathology and recovery in acute kidney injury.

ABSTRACT:

Purpose

Acute kidney injury (AKI) progression involves complex microcirculatory and structural changes poorly captured by conventional metrics. This study investigates contrast-enhanced ultrasound (CEUS) and shear wave elastography (SWE) to evaluate hemodynamic redistribution and fibrosis in AKI patients.

Methods

Prospective cohort study of 16 biopsy-confirmed tubulointerstitial (TI) nephritis patients and matched controls. We aim to explore the potential correlation of CEUS-SWE derived parameters (peak intensity (PI), rise time (RT), time to peak (TTP), and shear wave velocity (SWV)) with renal histopathology and 3-month outcomes (renal recovery: estimated glomerular filtration rate (eGFR) ≥45 mL/min/1.73 m²).

Results

CEUS revealed stage-specific perfusion

SUBMITTER: Wang X 

PROVIDER: S-EPMC12332991 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature