Gut microbiome and peritoneal inflammation: a new perspective on peritoneal dialysis-associated peritonitis.

ABSTRACT:

Background

Gut microbiome disorders and intestinal barrier damage were found in peritonitis. However, the relationship between the gut microbiome and peritoneal dialysis-associated peritonitis (PDAP) remains unknown. This study aimed to investigate the role of the gut microbiome in PDAP and explore its correlation with intra-abdominal inflammation.

Methods

We used a two-fold strategy to investigate the causal relationship between the gut microbiome and PDAP. First, a Mendelian randomization (MR) study was conducted using summarized statistics from genome-wide association studies (GWAS) of the gut microbiome and peritonitis. Additionally, a case-control study with 24 patients from the peritoneal dialysis (PD) and PDAP groups were conducted to validate the role of candidate ba

SUBMITTER: Xu P 

PROVIDER: S-EPMC12332992 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature