COG1410 Alleviated Chronic Sleep Deprivation-Induced Memory Loss by Regulating Microglial Phagocytosis and Inhibiting Hippocampal Inflammation.

ABSTRACT: It is widely recognized that sleep loss harms healthy adults. Microglia-mediated synaptic pruning is active during sleep and contributes to memory consolidation. Here, we established a mouse model of sleep deprivation (SD) using a modified multiple-platform method (MMPM). Using western blotting, immunofluorescence, and Golgi-Cox staining, we found that SD increased microglial capacity for phagocytizing mature synapses and decreased the number of mature synapses, which affected long-term memory consolidation but did not affect working memory after SD. Further, we discovered that pretreatment with the APOE mimic peptide COG1410 could partially rescue SD-induced long-term memory consolidation. Regarding the mechanism, COG1410 alleviated SD-induced abnormal microglial phagocytosis and increase

SUBMITTER: Wu P 

PROVIDER: S-EPMC12333007 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature