Selective Modulation of Trk Receptors by <i>Cyclo</i>-Organopeptides.

ABSTRACT: Neurotrophins (NTs, including NGF, BDNF, NT-4, and NT-3) are extracellular cytokines which modulate the survival and growth of cells expressing tropomyosin receptor kinases (Trks) A-C. Cells which express Trks include many neural tissues. For instance, corneal nerves secrete NTs to counteract epithelium disruption. Potential therapeutic applications of Trk agonism are numerous, but the use of NTs is limited by problems with production, in vivo stability, and side effects of the protein. Only humanized recombinant NGF has been clinically approved: Cenegermin for treatment of neurotrophic keratitis (NK) in the eye. Consequently, low molecular mass Trk agonists are of interest as surrogates for humanized NTs. One low molecular mass TrkA modulator from our lab, a cyclo-organopeptide

SUBMITTER: Joy S 

PROVIDER: S-EPMC12333011 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature