Profiling the Impact of mGlu₇/Elfn1 Protein Interactions on the Pharmacology of mGlu₇ Allosteric Modulators.

ABSTRACT: The group III metabotropic glutamate receptors (mGlu receptors) are predominantly expressed presynaptically throughout the central nervous system (CNS) where they regulate the release of glutamate and GABA. These receptors have recently been shown to be anchored by transsynaptic expression of the laminin proteins ELFN1 and ELFN2. In particular, the mGlu₇ receptor is localized at presynaptic active zones from pyramidal cells to somatostatin-containing interneurons with postsynaptic ELFN1, and this interaction drives the rapidly facilitating nature of these synapses in the hippocampus and cortex. Interestingly, individuals with mutations in ELFN1 or GRM7 genes present with attention-deficit hyperactivity disorder and epilepsy, and knockout mice of each of these prote

SUBMITTER: Lei X 

PROVIDER: S-EPMC12333015 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature