Nanodesigner: resolving the complex-CDR interdependency with iterative refinement.

ABSTRACT: Camelid heavy-chain only antibodies consist of two heavy chains and single variable domains (VHHs), which retain antigen-binding functionality even when isolated. The term "nanobody" is now more generally used for describing small, single-domain antibodies. Several antibody generative models have been developed for the sequence and structure co-design of the complementarity-determining regions (CDRs) based on the binding interface with a target antigen. However, these models are not tailored for nanobodies and are often constrained by their reliance on experimentally determined antigen-antibody structures, which are labor-intensive to obtain. Here, we introduce NanoDesigner, a tool for nanobody design and optimization based on generative AI methods. NanoDesigner integrates key stages-struc

SUBMITTER: Rios Zertuche MM 

PROVIDER: S-EPMC12333243 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature