Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts.

ABSTRACT: Opportunistic microbial pathogens that infect humans must adapt to radically different fitness landscapes as they transition from the external environment to the host niche. The nature, frequency, and magnitude of genomic changes that accompany adaptation to the human host niche are not well understood for many eukaryotic pathogens because of the logistical challenges of obtaining longitudinal samples of pathogen populations in individual patients. Drawing on a set of case studies, we characterize in-host genomic and phenotypic evolution of the opportunistic human fungal pathogen Cryptococcus neoformans during chronic infections. We find that fungal genome evolution during chronic infection is characterized by large-scale genome restructuring and increasing genomic heterogeneity within hos

SUBMITTER: Montoya MC 

PROVIDER: S-EPMC12333555 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature