Neutrophil Integrin α9 Impairs Efferocytosis and Worsens Long-Term Recovery After Subarachnoid Hemorrhage.

ABSTRACT:

Background

Neutrophil infiltration exacerbates brain injury after subarachnoid hemorrhage (SAH). Integrin α9, expressed on neutrophils, facilitates their adhesion and transendothelial migration, leading to aggravated inflammatory responses and neuronal apoptosis. Insufficient clearance of apoptotic neurons by microglia and infiltrating blood-derived macrophages (defective efferocytosis) contributes to persistent inflammation and poor SAH recovery. This study investigated the role of neutrophil integrin α9 in neuronal apoptosis, microglia/macrophage efferocytosis, and SAH outcomes.

Methods

Neutrophil-specific α9^-/- (α9^fl/flMrp8Cre^-/+) and littermate control (α9^fl/flMrp8Cre</

SUBMITTER: Kaur H 

PROVIDER: S-EPMC12333561 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature