Relationship between updated MELD and prognosis in alcohol-associated hepatitis: Opportunities for more efficient trial design.

ABSTRACT:

Background

Alcohol-associated hepatitis (AH) is associated with significant mortality. Model for End-Stage Liver Disease (MELD) score is used to predict short-term mortality and aid in treatment decisions. MELD is frequently updated in the course of AH. However, once the most updated MELD is known, it is uncertain if previous ones still have prognostic value, which might be relevant for transplant allocation and trial design. We aimed to investigate the predictive performance of updated MELDs in a prospectively collected cohort of patients with AH by the InTeam consortium.

Methods

Three hundred seven patients (with 859 MELD values within 60 d of admission) fulfilled the inclusion criteria. The main endpoint was time to death or transplant up to 90 days. We used a joint model

SUBMITTER: Al-Karaghouli M 

PROVIDER: S-EPMC12333734 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature