Long-term HBV infection of engineered cultures of induced pluripotent stem cell-derived hepatocytes.

ABSTRACT:

Background

HBV infects ~257 million people and can cause hepatocellular carcinoma. Since current drugs are not curative, novel therapies are needed. HBV infects chimpanzee and human livers. However, chimpanzee studies are severely restricted and cost-prohibitive, while transgenic/chimeric mouse models that circumvent the species barrier lack natural HBV infection and disease progression. Thus, in vitro human models of HBV infection are useful in addressing the above limitations. Induced pluripotent stem cell-derived hepatocyte-like cells mitigate the supply limitations of primary human hepatocytes and the abnormal proliferation/functions of hepatoma cell lines. However, variable infection across donors, deficient drug metabolism capacity, and/or low throughput limit iHep utility fo

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC12333802 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature