Longitudinal diffusion tensor imaging correlates with amyloid burden in Down syndrome.

ABSTRACT: Adults with Down syndrome (DS) accumulate amyloid beta (Aβ) plaques faster and earlier on average than neurotypical adults with sporadic Alzheimer's disease (AD). White matter (WM) microstructure characterized with diffusion tensor imaging (DTI) can indicate underlying architectural changes in longitudinal studies, suggestive of neurodegeneration. This study investigated relationships between DTI and Aβ in DS along the AD continuum. Using longitudinal amyloid Pittsburgh compound B positron emission tomography, Centiloid (CL) and DTI parameters were examined in 35 adults with DS ages 25 to 57. DTI measures of anisotropy and diffusivity were analyzed using tract-based spatial statistics and permutation analysis of linear models, testing for significant correlation between the rates of change

SUBMITTER: LeMerise LG 

PROVIDER: S-EPMC12333877 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature