Ribo-Seq Analysis-Based Elucidation of the Dynamic Translation Landscape of Yak Ovarian Tissues in Different Reproductive Stages.

ABSTRACT: Translation, plays a critical regulatory role in follicular development, ovulation, and corpus luteum formation and degeneration in the ovaries. To better understand the molecular mechanisms of reproductive regulation at the translation level in yaks, the present study analyzed gene expression changes in the ovarian tissues of yaks in different reproductive stages by using ribosome profiling and integrating RNA sequencing data. The small open reading frames (sORFs) of the ovarian tissue were characterized, and the effect of the translation efficiency of the targeted genes on their sequence features was determined. The results showed that over 80% of genes in the two groups exhibited inconsistent changes in their expression at the transcription and translation levels; this finding indicated

SUBMITTER: Hu L 

PROVIDER: S-EPMC12333925 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature