Immunomodulation of inflammatory responses preserves retinal integrity in murine models of pericyte-depletion retinopathy.

ABSTRACT: The loss of integrity of the blood retina barrier (BRB) is a key pathological hallmark of vision-threatening complications in diabetic retinopathy (DR). Although DR is considered a microvascular disease, mounting evidence from mouse models and patients show that inflammation is closely connected with microvasculopathy. Inflammatory responses during retinal pathophysiology are often orchestrated by microglia, resident innate immune cells of the retina. However, the precise role of microglia activity during DR pathogenesis remains elusive. Here, we used an anti-PDGFRβ antibody and inducible endothelial cell-specific PDGFB-KO during postnatal development of retinal vasculature to reproduce a key feature of DR pathology in mice. In addition, we applied a minocycline therapy to modulate retinal

SUBMITTER: Kinuthia UM 

PROVIDER: S-EPMC12333950 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature