NAT10-mediated ac4C modification of Lipin1 mRNA contributes to the pathogenesis of PWMI.

ABSTRACT: Preterm white matter injury (PWMI) is a leading cause of cerebral palsy and chronic neurological disabilities in premature infants. It is characterized by defects in oligodendrocyte precursor cell (OPC) differentiation and dysmyelination. Currently, there are no effective therapeutic strategies available in clinical practice. Lipid homeostasis plays a crucial role in myelin development, yet the function of Lipin1 - a key phosphatidic acid phosphatase involved in phospholipid synthesis - remains unclear. In this study, we identified a significant downregulation of Lipin1 in OPCs from PWMI mice, which impaired OPC differentiation and myelin formation. Conversely, Lipin1 overexpression in these mice promoted OPC maturation and enhanced myelin development. We found evidence that N-acetyltransf

SUBMITTER: Li X 

PROVIDER: S-EPMC12333955 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature