Vaccination with antigenically complex hemagglutinin mixtures confers broad protection from influenza disease.

ABSTRACT: Current seasonal influenza virus vaccines induce responses primarily against immunodominant but highly plastic epitopes in the globular head of the hemagglutinin (HA) glycoprotein. Because of viral antigenic drift at these sites, vaccines need to be updated and readministered annually. To increase the breadth of influenza vaccine-mediated protection, we developed an antigenically complex mixture of recombinant HAs designed to redirect immune responses to more conserved domains of the protein. Vaccine-induced antibodies were disproportionally redistributed to the more conserved stalk of the HA without hindering, and in some cases improving, antibody responses against the head domain. These improved responses led to increased protection against homologous and heterologous viral challenges in

SUBMITTER: Luo Z 

PROVIDER: S-EPMC12333966 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature