Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis.

ABSTRACT: Two-component signal transduction systems, comprised of histidine kinases and their response regulator substrates, are the predominant means by which bacteria sense and respond to extracellular signals. These systems allow cells to adapt to prevailing conditions by modifying cellular physiology, including initiating programs of gene expression, catalyzing reactions, or modifying protein-protein interactions. These signaling pathways have also been demonstrated to play a role in coordinating bacterial cell cycle progression and development. Here we report a system-level investigation of two-component pathways in the model organism Caulobacter crescentus. First, by a comprehensive deletion analysis we show that at least 39 of the 106 two-component genes are required for cell cycle progressio

SUBMITTER: Skerker JM 

PROVIDER: S-EPMC1233412 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature