Aqueous Synthesis of Poly(ethylene glycol)-amide-Norbornene-Carboxylate for Modular Hydrogel Crosslinking.

ABSTRACT: Poly(ethylene glycol)-norbornene (e.g., PEGNB) is a versatile macromer amenable to step-growth thiol-norbornene photopolymerization and inverse electron demand Diels-Alder (iEDDA) click reaction. The translational potentials of PEGNB-based hydrogels have been realized in the areas of stem cell differentiation, in vitro disease modeling, implantable therapeutic devices, and controlled release of therapeutics. Even with these advances, prior methods for synthesizing PEGNB all required heavy use of organic solvents that pose significant environmental and personal health burdens. Here, we report an all-aqueous synthesis of PEG-amide-norbornene-carboxylate (PEGaNB_CA) via reacting carbic anhydride (CA) with multi-arm amino-terminated PEG. Like previously reported ester-bearing

SUBMITTER: Dimmitt NH 

PROVIDER: S-EPMC12334186 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature