PGC1α regulates the mitochondrial metabolism response to cyclic stretch, which inhibits neointimal hyperplasia.

ABSTRACT: Neointimal hyperplasia occurs in the context of vascular injury, such as stent intervention or balloon angioplasty. However, the role of mechanical forces in this process remains to be studied. In this study, a rat carotid artery intimal injury model was established. RNA-sequencing and transmission electron microscopy revealed that intimal injury disrupted the balance of vascular energy metabolism and impaired the mitochondrial ultrastructure in vivo. The human carotid plaque and femoral artery plaque samples also exhibited alterations in mitochondrial morphology. Vascular smooth muscle cells (VSMCs) are the main components of neointimal hyperplasia and are subjected to cyclic stretch resulting from pulsatile pressure. In this study, we found that the application of cyclic stretch in vitro

SUBMITTER: Zou M 

PROVIDER: S-EPMC12334387 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature