Efficacy and safety analysis of different treatment regimens in newly diagnosed acute promyelocytic leukemia.

ABSTRACT: This retrospective study analyzed the clinical data of 151 newly diagnosed adult acute promyelocytic leukemia (APL) patients during induction therapy at Qilu Hospital of Shandong University to compare the efficacy and complications of different treatment regimens in low-to-intermediate-risk (WBC < 10 × 10⁹/L) and high-risk (WBC ≥ 10 × 10⁹/L) patients. Low-to-intermediate-risk patients were divided into three groups: ATRA + ATO dual induction (n = 18), ATRA + ATO + single-agent chemotherapy (n = 63), and ATRA + ATO + dual-agent chemotherapy (n = 18). High-risk patients were divided into two groups: ATRA + chemotherapy (n = 11) and ATRA + ATO + chemotherapy (n = 41). Results showed no significant differences in early mortality (0% vs. 3.17% vs. 5.56%), complete remission rates (94.44% vs. 96

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12334416 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature