Feasibility analysis of metabolic parameters based on baseline ¹⁸F-FDG PET/CT to predict heterogeneity and recurrence of diffuse large B-cell lymphoma.

ABSTRACT:

Objective

This study aimed to evaluate the predictive value of intra-tumoral ¹⁸F-FDG metabolic heterogeneity in patients with diffuse large B cell lymphoma (DLBCL) in terms of survival.

Methods

We retrospectively included 245 patients with DLBCL who underwent ¹⁸F-FDG PET/CT prior to treatment and analyzed using total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) as metabolic volume parameters. The linear regression slopes of TMTV and TLG were calculated according to different percentages of SUV thresholds (i.e., 40%, 50%, 60%, 70%, and 80%), respectively, defined as Heterogeneity Factor-1 (HF1) and Heterogeneity Factor-2 (HF2). These indices of heterogeneity were used to predict progression-free survival (PFS). Based on the results of

SUBMITTER: Ge F 

PROVIDER: S-EPMC12334437 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature