Brentuximab vedotin plus CHP-like regimen for the first-line treatment of PTCL patients: a real-world single center study.

ABSTRACT: To evaluate the efficacy and safety of brentuximab vedotin (BV) combined with a CHP-like regimen (cyclophosphamide, doxorubicin, and prednisone) as first-line treatment for newly diagnosed peripheral T-cell lymphoma (PTCL). We retrospectively analyzed the clinical data of patients with PTCL who received BV in combination with a CHP-like regimen as first-line therapy between January 2021 and October 2023. Fifty patients were included in this study, with a median age of 57 years (rang, 22-86 years). The median number of BV cycles administered was six (range, 2-8 cycles). After a median follow-up of 35.2 months (95% confidence interval [CI], 30.9-39.5), the overall response rate (ORR) was 80%, with 44% of the patients achieving a complete response (CR). In patients with the ALK-positive anapl

SUBMITTER: Guan F 

PROVIDER: S-EPMC12334440 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature