Modelling the Impact of Phenotypic Heterogeneity on Cell Migration: A Continuum Framework Derived from Individual-Based Principles.

ABSTRACT: Collective cell migration plays a crucial role in numerous biological processes, including tumour growth, wound healing, and the immune response. Often, the migrating population consists of cells with various different phenotypes. This study derives a general mathematical framework for modelling cell migration in the local environment, which is coarse-grained from an underlying individual-based model that captures the dynamics of cell migration that are influenced by the phenotype of the cell, such as random movement, proliferation, phenotypic transitions, and interactions with the local environment. The resulting, flexible, and general model provides a continuum, macroscopic description of cell invasion, which represents the phenotype of the cell as a continuous variable and is much more

SUBMITTER: Crossley RM 

PROVIDER: S-EPMC12334544 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature