Microglial Activation and Inflammatory Responses in Parkinson's Disease Models Are Attenuated by TRPM2 Depletion.

ABSTRACT: Inflammation, and particularly microglial cells, has become a central feature in Parkinson's disease (PD) pathology. The transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable nonselective channel involved in the pathological mechanism of several inflammatory and neurodegenerative diseases. However, the role of TRPM2 in inflammation and microglial activation in the context of PD remains unclear. Here, we combined both in vivo and in vitro PD models to investigate that question. Male and female TRPM2 partial and complete knockout mice were submitted to the 6-hydroxidopamine mouse model of PD. We assessed microglia and lysosome-associated protein (CD68) density levels, microglial morphology and cluster classification, CD68 area in individual microglial cells, and the protei

SUBMITTER: Ferreira AFF 

PROVIDER: S-EPMC12334870 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature