A Single Early-Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung.

ABSTRACT: Whether early-life acetaminophen (APAP) exposures injure the developing lung is controversial. We sought to correlate murine pulmonary developmental expression profiles of Cyp2e1 to susceptibility to APAP exposure. Postnatal day 14 (P14) C57BL/6 mice were exposed to APAP (140 mg/kg × 1 i.p.) and assessed for evidence of a histologic, metabolic, functional, and/or transcriptional pulmonary response. Similar experiments were performed in P14 IL6^-/- mice, given the controversial role of IL-6 in APAP-induced tissue injury. No evidence of hepatic injury was noted in APAP-exposed P14 mice. In contrast, within 6 hours of exposure, pulmonary tissue demonstrated histologic and functional evidence of injury and increased mitochondrial load by fluorescence lifetime imaging microscop

SUBMITTER: Grayck MR 

PROVIDER: S-EPMC12334886 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature