Antibiotic Use and the Risk of Hospital-Onset Clostridioides Difficile Infection.

ABSTRACT:

Importance

Clostridioides difficile is a leading cause of health care-associated infections. Understanding the association among C difficile carriage, antibiotic use, and infection hazard is essential for infection prevention.

Objective

To evaluate the hazard of C difficile infection (CDI) among asymptomatic carriers vs noncarriers of C difficile and whether it is associated with antibiotic exposure.

Design, setting, and participants

This retrospective cohort study conducted between June 18, 2017, and June 21, 2023, analyzed hospitalizations from Sheba Medical Center in Ramat Gan, Israel, which routinely screens for C difficile in high-risk patients admitted to internal medicine. Adult patients (aged >18 years) without active CDI at admission were included.

Exposur

SUBMITTER: Gilboa M 

PROVIDER: S-EPMC12334957 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature