A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging.

ABSTRACT: Hyperpolarized (HP) gas pulmonary MR ventilation images are typically quantified using ventilation defect percent (VDP); however, the test-retest variability of VDP has not been systematically established in multi-center trials. Herein, we perform a systematic review of the test-retest literature on the variability of VDP, and similar metrics, generated from HP MRI. This review utilizes the Medline, EMBASE, and EBM Reviews databases and includes studies that assessed the variability of HP MRI VDP. The protocol was registered to PROSPERO: CRD42022328535. Imaging techniques and statistical analysis characteristics were extracted and used to group studies to evaluate the overall ability to pool data across grouped studies. The ability to pool data to provide systematic evidence was assessed u

SUBMITTER: Diamond VM 

PROVIDER: S-EPMC12335342 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature