Brain Tumor Characterization Using Multiple MR Parameters From Multi-Contrast EPI With Keyhole (GE-SE EPIK) Including Oxygen Extraction Fraction: A Comparison to O-(2-[18F]Fluoroethyl)-L-Tyrosine (FET) Positron Emission Tomography.

ABSTRACT:

Background

Tumor characterization and treatment efficacy are associated with tissue hypoxia. MR-derived oxygen extraction fraction (OEF) may offer valuable tumor insights but depends on multiple measurement parameters, often requiring multiple sequence acquisitions. Specific multi-parametric sequences offer direct access to MR parameter sets within short acquisition times.

Purpose

To evaluate the potential of gradient-echo spin-echo echo-planar imaging with keyhole (GE-SE EPIK)-derived parameters (OEF/T₂/T₂*/venous cerebral blood volume (vCBV)) to characterize increased metabolic activity tissue identified in [¹⁸F]fluoroethyl-L-tyrosine (FET) PET, serving as a surrogate for neoplastic tissue.

Study type

Retrospective.

Population

SUBMITTER: Kuppers F 

PROVIDER: S-EPMC12335343 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature