PDIA3 rs2788, a risk factor for metabolic syndrome, interacted negatively with antihypertensive medications.

ABSTRACT: The clinical complex called metabolic syndrome (MetS) is caused by the interaction of genetic and cardiovascular risk factors. Protein disulfide isomerase family A member 3 (PDIA3) is a key endoplasmic reticulum protein which may contribute to MetS. This study aimed to evaluate how PDIA3 polymorphism is linked to MetS and its hypertension. Clinical indicators were measured in 2,379 individuals. The association of PDIA3 rs2788 with MetS was analyzed. Crossover analysis elucidated the crosstalk between PDIA3 rs2788 and antihypertensive treatment, and the synergistic effect on MetS. In this cross-sectional study, linear regression analysis showed that a positive linear correlation of rs2788 with systolic blood pressure (SBP, β = 5.818, p < 0.01) and diastolic blood pressure (DBP, β = 4.324, p

SUBMITTER: Zheng M 

PROVIDER: S-EPMC12335593 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature