Comprehensive analysis of diagnostic biomarkers related to histone acetylation in acute myocardial infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI) has become a serious disease that endangers human health, with high morbidity and mortality. Numerous studies have reported histone acetylation can result in the occurrence of cardiovascular diseases. This article aims to explore the potential biomarkers of histone acetylation regulatory genes (ARGs) in AMI patients.

Methods

Five AMI datasets were downloaded from the Gene Expression Omnibus (GEO) database. Next, ARG-related genes were gathered by gene set variation analysis (GSVA) and Spearman's correlation analysis. Subsequently, weighted gene co-expression network analysis (WGCNA) was performed to identify the module genes related to histone acetylation regulation. In the GSE60993 and GSE48060 datasets, the common differentially

SUBMITTER: Li M 

PROVIDER: S-EPMC12335776 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature