Hyperorality in Frontotemporal Dementia: How Psychiatric and Neural Correlates Change During the Disease Course.

ABSTRACT:

Objective

Hyperorality is a core feature of behavioral variant frontotemporal dementia (bvFTD); however, the cognitive, psychiatric, and neuroanatomical correlates of hyperorality across the bvFTD stages remain unclear. The authors explored these associations in early- and advanced-stage bvFTD.

Methods

Participants with sporadic or genetic bvFTD were enrolled in the ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) consortium study. Baseline cognitive and psychiatric symptoms of participants with or without hyperorality were compared after stratification by disease severity. Linear multivariable regressions adjusted for age and total intracranial volume were used to examine associations between regional gray matter volume (GMV) and hyperorality status. Fi

SUBMITTER: Morrow CB 

PROVIDER: S-EPMC12335828 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature