Conformational response of α_IIbβ₃ and α_Vβ₃ integrins to force.

ABSTRACT: As major adhesion receptors, integrins transmit biochemical and mechanical signals across the plasma membrane. These functions are regulated by transitions between bent and extended conformations and modulated by force. To understand how force on integrins mediates cellular mechanosensing, we compared two highly homologous integrins, α_IIbβ₃ and α_Vβ₃. These integrins, expressed in circulating platelets vs. solid tissues, respectively, share the β₃ subunit, bind similar ligands and have similar bent and extended conformations. Here, we report that in cells expressing equivalent levels of each integrin, α_IIbβ₃ mediates spreading on softer substrates than α_Vβ₃. These effects correlate with differ

SUBMITTER: Kolasangiani R 

PROVIDER: S-EPMC12335895 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature