Genomic analysis and molecular profiling of dengue viruses in Sabah, Malaysia during 2019-2020.

ABSTRACT:

Objectives

Limited information is available on the distribution of dengue virus (DENV) serotypes and genotypes in Borneo, particularly, in Sabah, because most studies have focused on Peninsular Malaysia. This study aimed to investigate the serologic and molecular epidemiologic characteristics of DENV in patients from Sabah.

Methods

Serum samples were collected from febrile patients in Kota Kinabalu and Lahad Datu between 2019 and 2020 at the Kota Kinabalu Public Health Laboratory. We performed virus isolation, serological testing, viremia quantification, and complete genome sequencing.

Results

Of 188 serum samples, 89 tested positive for DENV by quantitative reverse transcription-polymerase chain reaction: 20 DENV-1, 46 DENV-2, 20 DENV-3, and 1 DENV-4. A total of 38 v

SUBMITTER: Ngwe Tun MM 

PROVIDER: S-EPMC12336003 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature