Colopathy associated with pentosan polysulfate use.

ABSTRACT:

Introduction

We describe a novel colopathy associated with pentosan polysulfate (PPS) use and assess the strength of the drug-disease association in a two-part investigation.

Methods

1. Cohort Study: We studied individuals with a history of long-term PPS use. Case histories concerning gastrointestinal disease were obtained with review of endoscopy records and histopathology specimens. Findings were summarized with descriptive statistics. 2. Cross-Sectional Study: We evaluated patients with interstitial cystitis at a single clinical center. We obtained data on drug exposure and medical histories and measured the strength of association between PPS use and diagnosis of inflammatory bowel disease (IBD) using multivariate logistic regression.

Results

1. Cohort Study: Amon

SUBMITTER: Jung EH 

PROVIDER: S-EPMC12336275 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature