The risk of epilepsy after neonatal seizures.

ABSTRACT:

Aim

To estimate the cumulative risk of epilepsy after neonatal seizures and identify subpopulations at increased risk.

Method

This was a nationwide register-based cohort study including all children born in Denmark between 1997 and 2018. The cumulative risk of epilepsy in children with and without neonatal seizures was compared. Furthermore, neonatal seizures were stratified according to aetiology.

Results

We followed 1 294 377 children and identified 1998 neonatal survivors with neonatal seizures. The cumulative risk of epilepsy was 20.4% (95% confidence interval [CI] = 18.5-22.3) among children with neonatal seizures, compared to 1.15% (95% CI = 1.12-1.18) among children without. Epilepsy was diagnosed before 1 year of age in 11.4% of children with neonatal seizures

SUBMITTER: Tinggaard J 

PROVIDER: S-EPMC12336401 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature