Identification of biomarkers of male infertility through the circRNA expression profiling of seminal plasma.

ABSTRACT: Circular RNAs (circRNAs) are key regulators of reproductive biology. However, limited information is available regarding circRNA expression profiles in seminal plasma samples from individuals with male infertility. The present study aimed to identify circRNAs associated with infertility in seminal plasma samples and to clarify their potential as biomarkers, as well as the possible molecular mechanisms underlying their functions. Next-generation RNA sequencing was conducted to analyze circRNA profiles in seminal plasma from healthy controls, oligoasthenospermia (OAZ) patients, and non-obstructive azoospermia (NOA) patients. Bioinformatics analysis revealed that 637 circRNAs were differentially expressed between OAZ and control subjects, and 272 circRNAs were differentially expressed between

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12336409 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature