Post-transcriptional dysregulation in autism, schizophrenia, and bipolar disorder.

ABSTRACT: The alteration of gene expression is not restricted to transcriptional regulation but includes a variety of post-transcriptional mechanisms; however, the role of the latter in many diseases remains relatively unknown. By using an RNA-Seq dataset of 1510 brain samples from individuals with autism spectrum disorder (ASD), bipolar disorder (BD), schizophrenia (SCZ), and controls, we assessed the contribution of post-transcriptional dysregulation and identified top perturbators accountable for transcriptomic alterations in neuropsychiatric disorders. Approximately 30% of the expression variability was attributed to post-transcriptional dysregulation. Interestingly, mature mRNA levels tended to be post-transcriptionally downregulated in SCZ and BD, leading to the inhibition of neurogenesis and

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12336410 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature