Antigenic distance between primary and secondary dengue infections correlates with disease risk.

ABSTRACT: Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection even in previously exposed individuals. In addition, for some pathogens, such as dengue virus, poorly targeted immunity is associated with increased risk of severe disease through a mechanism known as antibody-dependent enhancement. However, it remains unclear whether the antigenic distances between an individual's first infection and subsequent exposures dictate disease risk, explaining the observed large-scale differences in dengue hospitalizations across years. Here, we develop a framework that combines detailed antigenic and genetic characterization of viruses with details on hospitalized cases from 21 years of dengue surveillance in Bangkok, Thailand, to

SUBMITTER: Wang L 

PROVIDER: S-EPMC12336440 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature