Exploring the Single-Cell Dynamics of FOXM1 Under Cell Cycle Perturbations.

ABSTRACT: The cell cycle is crucial for maintaining normal cellular functions and preventing replication errors. FOXM1, a key transcription factor, plays a pivotal role in regulating cell cycle progression and is implicated in various physiological and pathological processes, including cancers like liver, prostate, breast, lung and colon cancer. Despite previous research, our understanding of FOXM1 dynamics under different cell cycle perturbations and its connection to heterogeneous cell fate decisions remains limited. In this study, we investigated FOXM1 behaviour in individual cells exposed to various perturbagens. We found that different drugs induce diverse responses due to heterogeneous FOXM1 dynamics at the single-cell level. Single-cell analysis identified six distinct cellular phenotypes: on

SUBMITTER: Jawwad T 

PROVIDER: S-EPMC12336449 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature